| | | Sunday, March 7th, 2021 | | Signed free agent C Eric Gross to a minor league contract. |
| Monday, March 1st, 2021 | | Drafted CF Gerardo Toledo in the 2021 first-year player draft (Round 1, Pick 12, 12th overall pick). | | Drafted CF Jesse Bonsall in the 2021 first-year player draft (Round 2, Pick 15, 47th overall pick). | | Drafted C Ray Washington in the 2021 first-year player draft (Round 3, Pick 15, 79th overall pick). | | Drafted SP Louie Sackett in the 2021 first-year player draft (Round 4, Pick 16, 113rd overall pick). | | Drafted 3B Allan Cleveland in the 2021 first-year player draft (Round 5, Pick 10, 141st overall pick). | | Drafted CF Keith Eaton in the 2021 first-year player draft (Round 6, Pick 10, 182nd overall pick). | | Drafted CF Clyde Blenkin in the 2021 first-year player draft (Round 7, Pick 10, 217th overall pick). | | Drafted RF Julius Smith in the 2021 first-year player draft (Round 8, Pick 10, 241st overall pick). | | Drafted SP Albert McClarnon in the 2021 first-year player draft (Round 9, Pick 10, 265th overall pick). | | Drafted RF Jason Lewis in the 2021 first-year player draft (Round 10, Pick 10, 289th overall pick). |
| Friday, February 12th, 2021 | | C Jorge Flores was designated for assignment and placed on waivers. | | Placed 2B Jed Mathis on the 40-man roster. | | Placed 2B Jed Mathis on the active roster. |
| Thursday, January 28th, 2021 | | Signed free agent 2B Jed Mathis to a 1-year contract worth a total of $1,090,000. |
| Wednesday, January 27th, 2021 | | Signed free agent C Jorge Flores to a 1-year contract worth a total of $750,000. |
| Wednesday, January 13th, 2021 | | Placed MR Pedro Torres on the USBA Triple A 15-day disabled list. |
| Wednesday, January 6th, 2021 | | Signed free agent 2B Bernardo Vázquez to a 1-year contract worth a total of $3,020,000. |
| Monday, December 21st, 2020 | | Signed free agent SS Bernardo Munguia to a 4-year contract worth a total of $38,480,000. |
| Tuesday, December 8th, 2020 | | Signed free agent MR Iván González to a 2-year contract worth a total of $7,660,000. |
| Wednesday, November 25th, 2020 | | SS Iván Ruíz becomes a free-agent. | | MR Jesús Hernández becomes a free-agent. | | 3B Jorge Sáenz becomes a free-agent. | | SP Brennan Randolph received a 1-year contract through automatic renewal worth a total of $400,000. | | 3B Ferguson Roberts received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Ken Jones received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Larry Bryan received a 1-year contract through automatic renewal worth a total of $400,000. | | C Lúcio Cortéz becomes a free-agent. | | C Dave Turner received a 1-year contract through automatic renewal worth a total of $400,000. | | CF Doyle Griffith received a 1-year contract through automatic renewal worth a total of $400,000. | | 2B Akutla Kenyatta received a 1-year contract through automatic renewal worth a total of $400,000. | | RF Jorge Vázquez received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Jorge López received a 1-year contract through automatic renewal worth a total of $400,000. | | MR John Whitley becomes a free-agent. | | SP Gus Thompson becomes a free-agent. | | MR Joe Brown becomes a free-agent. | | SS Craig Bailey becomes a free-agent. | | MR Orlando Pérez becomes a free-agent. | | LF Rory Hernández becomes a free-agent. |
| Sunday, November 22nd, 2020 | | CF Juan Vásquez received a 1-year contract through arbitration worth a total of $600,000. | | MR Ted Brady received a 1-year contract through arbitration worth a total of $1,620,000. | | 2B Stuart Thomas received a 1-year contract through arbitration worth a total of $3,360,500. | | 1B Anastasio Rodríguez received a 1-year contract through arbitration worth a total of $600,000. | | MR Jesús Martínez received a 1-year contract through arbitration worth a total of $600,000. | | SS Josh Kirby received a 1-year contract through arbitration worth a total of $600,000. | | C Ángel Ocampo received a 1-year contract through arbitration worth a total of $600,000. | | SS John Lacy received a 1-year contract through arbitration worth a total of $600,000. |
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