| | | Friday, February 12th, 2021 | | C Jorge Flores was designated for assignment and placed on waivers. | | Placed 2B Jed Mathis on the active roster. |
| Thursday, February 11th, 2021 | | Placed C Jorge Flores on the active roster. |
| Thursday, January 28th, 2021 | | Signed free agent 2B Jed Mathis to a 1-year contract worth a total of $1,090,000. |
| Wednesday, January 27th, 2021 | | Signed free agent C Jorge Flores to a 1-year contract worth a total of $750,000. |
| Wednesday, January 6th, 2021 | | Signed free agent 2B Bernardo Vázquez to a 1-year contract worth a total of $3,020,000. |
| Monday, December 21st, 2020 | | Signed free agent SS Bernardo Munguia to a 4-year contract worth a total of $38,480,000. |
| Tuesday, December 8th, 2020 | | Signed free agent MR Iván González to a 2-year contract worth a total of $7,660,000. |
| Wednesday, November 25th, 2020 | | SS Iván Ruíz becomes a free-agent. | | MR Jesús Hernández becomes a free-agent. | | 3B Jorge Sáenz becomes a free-agent. | | SP Brennan Randolph received a 1-year contract through automatic renewal worth a total of $400,000. | | 3B Ferguson Roberts received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Ken Jones received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Larry Bryan received a 1-year contract through automatic renewal worth a total of $400,000. | | C Lúcio Cortéz becomes a free-agent. | | C Dave Turner received a 1-year contract through automatic renewal worth a total of $400,000. | | CF Doyle Griffith received a 1-year contract through automatic renewal worth a total of $400,000. | | 2B Akutla Kenyatta received a 1-year contract through automatic renewal worth a total of $400,000. | | RF Jorge Vázquez received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Jorge López received a 1-year contract through automatic renewal worth a total of $400,000. |
| Sunday, November 22nd, 2020 | | CF Juan Vásquez received a 1-year contract through arbitration worth a total of $600,000. | | MR Ted Brady received a 1-year contract through arbitration worth a total of $1,620,000. | | 2B Stuart Thomas received a 1-year contract through arbitration worth a total of $3,360,500. | | 1B Anastasio Rodríguez received a 1-year contract through arbitration worth a total of $600,000. | | MR Jesús Martínez received a 1-year contract through arbitration worth a total of $600,000. | | SS Josh Kirby received a 1-year contract through arbitration worth a total of $600,000. | | C Ángel Ocampo received a 1-year contract through arbitration worth a total of $600,000. | | SS John Lacy received a 1-year contract through arbitration worth a total of $600,000. |
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