| | | Tuesday, April 20th, 2021 | | Placed CF Jesús Pérez on the USBA Double A 15-day disabled list. |
| Monday, April 19th, 2021 | | Placed MR Amal Chioh on the USBA Single A 15-day disabled list. |
| Sunday, April 4th, 2021 | | Placed LF Mike Setser on the 14-day disabled list. |
| Saturday, April 3rd, 2021 | | Activated LF Alberto Olvera from the disabled list. | | MR Javier Gonzáles was designated for assignment, placed on waivers and taken off the 40-man roster. |
| Wednesday, March 17th, 2021 | | Signed SP Larry Skiffington to a 1-year contract extension worth a total of $3,430,000. |
| Tuesday, March 16th, 2021 | | Signed free agent MR Josh King to a minor league contract. |
| Saturday, March 6th, 2021 | | Signed free agent SP Noel Novak to a minor league contract. |
| Monday, March 1st, 2021 | | Promoted CL Doug Bartlett from Double A Columbia to Triple A Surfside. | | Promoted 3B Nate Barker from Double A Columbia to Triple A Surfside. | | Promoted SP Alfonso Ramírez from Single A Fayetteville to Double A Columbia. | | Promoted SP Kent Johns from Single A Fayetteville to Double A Columbia. | | Promoted SP Ed Martínez from Single A Fayetteville to Double A Columbia. | | Promoted MR John Gates from Single A Fayetteville to Double A Columbia. | | Promoted MR Randy Russell from Single A Fayetteville to Double A Columbia. | | Promoted MR Curt Taylor from Single A Fayetteville to Double A Columbia. | | Promoted MR Sherman Sutton from Single A Fayetteville to Double A Columbia. | | Promoted MR Florent LaCroix from Single A Fayetteville to Double A Columbia. | | Promoted SS Gabriel Martínez from Single A Fayetteville to Double A Columbia. | | Promoted SS Jimmy Maloney from Single A Fayetteville to Double A Columbia. | | Promoted CF Jesús Pérez from Single A Fayetteville to Double A Columbia. | | Promoted RF Paul Thompson from Single A Fayetteville to Double A Columbia. | | Promoted SP Johnny Brown from Single A Fayetteville to Double A Columbia. | | Demoted SP Harvey McDermott from Double A Columbia to Single A Fayetteville. | | Demoted SS Rob Walker from Double A Columbia to Single A Fayetteville. | | Drafted CL Ronnie Albert in the 2021 first-year player draft (Round 1, Pick 28, 28th overall pick). | | Drafted MR Manny Hunt in the 2021 first-year player draft (Round 2, Pick 29, 61st overall pick). | | Drafted 3B Jorge Sánchez in the 2021 first-year player draft (Round 3, Pick 29, 93rd overall pick). | | Drafted RF Vince Barrón in the 2021 first-year player draft (Round 4, Pick 34, 131st overall pick). | | Drafted SP Michael Lee in the 2021 first-year player draft (Round 5, Pick 20, 151st overall pick). | | Drafted C Gregory Johnson in the 2021 first-year player draft (Round 5, Pick 31, 162nd overall pick). | | Released C Gregory Johnson. | | Drafted 2B Dean Collins in the 2021 first-year player draft (Round 6, Pick 20, 192nd overall pick). | | Drafted LF Juan González in the 2021 first-year player draft (Round 7, Pick 20, 227th overall pick). | | Drafted SP Merrill Baker in the 2021 first-year player draft (Round 8, Pick 20, 251st overall pick). | | Drafted SS Pancho Mercado in the 2021 first-year player draft (Round 9, Pick 20, 275th overall pick). | | Drafted SP Juan Cantú in the 2021 first-year player draft (Round 10, Pick 20, 299th overall pick). | | Promoted 2B Dean Collins from Single A Fayetteville to Double A Columbia. | | Demoted MR Johnny Brown from Double A Columbia to Single A Fayetteville. |
| Saturday, December 5th, 2020 | | Signed SS Jerry Anderson to a 4-year contract extension worth a total of $53,510,000. |
| Wednesday, November 25th, 2020 | | MR Lou Black received a 1-year contract through automatic renewal worth a total of $400,000. | | C Luis Costa received a 1-year contract through automatic renewal worth a total of $400,000. | | LF Pedro Torres becomes a free-agent. | | SP Jeff Joyce received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Roberto Vargas received a 1-year contract through automatic renewal worth a total of $400,000. | | 1B Víctor Sánchez becomes a free-agent. | | LF Alberto Olvera received a 1-year contract through automatic renewal worth a total of $400,000. | | 1B Andy Retter received a 1-year contract through automatic renewal worth a total of $400,000. | | 3B Ramiro Espińol received a 1-year contract through automatic renewal worth a total of $400,000. | | CF Jorge Cervantes becomes a free-agent. | | SP Caleb O'Cahaney becomes a free-agent. | | SP Forrest Hall becomes a free-agent. | | MR Dale Davis becomes a free-agent. | | Placed 1B Eric Hamilton on the 40-man roster. | | MR Roger Clark becomes a free-agent. |
| Sunday, November 22nd, 2020 | | MR Brian Chapman received a 1-year contract through arbitration worth a total of $600,000. | | LF Mike McNatt received a 1-year contract through arbitration worth a total of $600,000. | | 2B Jeffrey Reynolds received a 1-year contract through arbitration worth a total of $600,000. | | 1B Josh Dean received a 1-year contract through arbitration worth a total of $2,770,000. | | SP Ernesto Cervantes received a 1-year contract through arbitration worth a total of $600,000. | | RF Bob Boyd received a 1-year contract through arbitration worth a total of $2,292,000. | | CL Phil Lyons received a 1-year contract through arbitration worth a total of $5,220,000. | | MR Iván Ortíz received a 1-year contract through arbitration worth a total of $600,000. |
| Friday, November 20th, 2020 | | Signed free agent 3B Matt McKinley to a 2-year contract worth a total of $5,420,000. |
| Tuesday, November 17th, 2020 | | Signed free agent MR Dan Barnes to a 2-year contract worth a total of $4,500,000. |
| Friday, November 13th, 2020 | | Signed free agent 3B Joe Wynn to a 2-year contract worth a total of $5,720,000. |
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