| | | Sunday, April 4th, 2021 | | Placed LF Mike Setser on the 14-day disabled list. |
| Saturday, April 3rd, 2021 | | Activated LF Alberto Olvera from the disabled list. | | MR Javier Gonzáles was designated for assignment, placed on waivers and taken off the 40-man roster. |
| Wednesday, March 17th, 2021 | | Signed SP Larry Skiffington to a 1-year contract extension worth a total of $3,430,000. |
| Saturday, December 19th, 2020 | | Signed free agent SS Domingo Martínez to a 3-year contract worth a total of $30,680,000. |
| Wednesday, December 9th, 2020 | | Signed free agent MR Paco Arroyo to a 2-year contract worth a total of $5,280,000. |
| Saturday, December 5th, 2020 | | Signed SS Jerry Anderson to a 4-year contract extension worth a total of $53,510,000. |
| Wednesday, November 25th, 2020 | | MR Lou Black received a 1-year contract through automatic renewal worth a total of $400,000. | | C Luis Costa received a 1-year contract through automatic renewal worth a total of $400,000. | | LF Pedro Torres becomes a free-agent. | | SP Jeff Joyce received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Roberto Vargas received a 1-year contract through automatic renewal worth a total of $400,000. | | 1B Víctor Sánchez becomes a free-agent. | | LF Alberto Olvera received a 1-year contract through automatic renewal worth a total of $400,000. | | 1B Andy Retter received a 1-year contract through automatic renewal worth a total of $400,000. | | 3B Ramiro Espińol received a 1-year contract through automatic renewal worth a total of $400,000. |
| Sunday, November 22nd, 2020 | | MR Brian Chapman received a 1-year contract through arbitration worth a total of $600,000. | | LF Mike McNatt received a 1-year contract through arbitration worth a total of $600,000. | | 2B Jeffrey Reynolds received a 1-year contract through arbitration worth a total of $600,000. | | 1B Josh Dean received a 1-year contract through arbitration worth a total of $2,770,000. | | SP Ernesto Cervantes received a 1-year contract through arbitration worth a total of $600,000. | | RF Bob Boyd received a 1-year contract through arbitration worth a total of $2,292,000. | | CL Phil Lyons received a 1-year contract through arbitration worth a total of $5,220,000. | | MR Iván Ortíz received a 1-year contract through arbitration worth a total of $600,000. |
| Friday, November 20th, 2020 | | Signed free agent 3B Matt McKinley to a 2-year contract worth a total of $5,420,000. |
| Tuesday, November 17th, 2020 | | Signed free agent MR Dan Barnes to a 2-year contract worth a total of $4,500,000. |
| Friday, November 13th, 2020 | | Signed free agent 3B Joe Wynn to a 2-year contract worth a total of $5,720,000. |
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