| | | Monday, April 12th, 2021 | | Placed LF Elwood Moore on the USBA Double A 15-day disabled list. |
| Monday, March 1st, 2021 | | Drafted C Melvin Edwards in the 2021 first-year player draft (Round 1, Pick 29, 29th overall pick). | | Drafted CF Rocky Adams in the 2021 first-year player draft (Round 2, Pick 30, 62nd overall pick). | | Drafted CF Rafael Olvera in the 2021 first-year player draft (Round 3, Pick 30, 94th overall pick). | | Drafted MR Benny Dukes in the 2021 first-year player draft (Round 4, Pick 9, 106th overall pick). | | Drafted CF Roberto Delgado in the 2021 first-year player draft (Round 4, Pick 28, 125th overall pick). | | Drafted RF Ken Tanner in the 2021 first-year player draft (Round 4, Pick 37, 134th overall pick). | | Drafted CF Germán Árias in the 2021 first-year player draft (Round 5, Pick 21, 152nd overall pick). | | Drafted C Ronnie Weaver in the 2021 first-year player draft (Round 5, Pick 32, 163rd overall pick). | | Released C Ronnie Weaver. | | Drafted 2B John Christian in the 2021 first-year player draft (Round 6, Pick 21, 193rd overall pick). | | Drafted MR Vincente Valdéz in the 2021 first-year player draft (Round 7, Pick 21, 228th overall pick). | | Drafted RF Francisco Martínez in the 2021 first-year player draft (Round 8, Pick 21, 252nd overall pick). | | Drafted SP Edgardo García in the 2021 first-year player draft (Round 9, Pick 21, 276th overall pick). | | Drafted 2B António Guzmán in the 2021 first-year player draft (Round 10, Pick 21, 300th overall pick). |
| Thursday, February 4th, 2021 | | Signed free agent SP Lorenzo Medina to a 5-year contract worth a total of $60,300,000. |
| Saturday, January 23rd, 2021 | | Signed free agent SS Ernesto Valdés to a 3-year contract worth a total of $27,300,000. |
| Saturday, January 16th, 2021 | | Signed free agent LF Jorge Cuarenta to a 3-year contract worth a total of $12,480,000. |
| Sunday, November 22nd, 2020 | | DH Seth Becker received a 1-year contract through arbitration worth a total of $4,492,500. | | MR José Cortéz received a 1-year contract through arbitration worth a total of $700,000. | | 3B Jed Novak received a 1-year contract through arbitration worth a total of $600,000. | | 1B Richard Harrell received a 1-year contract through arbitration worth a total of $5,782,000. | | MR Gary Clark received a 1-year contract through arbitration worth a total of $1,210,000. | | 2B Milton Richter received a 1-year contract through arbitration worth a total of $3,605,000. | | C William Brown received a 1-year contract through arbitration worth a total of $600,000. | | RF Harlan Harding received a 1-year contract through arbitration worth a total of $4,400,000. | | 2B Foma Naboischikov received a 1-year contract through arbitration worth a total of $735,000. |
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