| Monday, March 1st, 2021 |
| Drafted LF Pablo Ruíz in the 2021 first-year player draft (Round 1, Pick 11, 11th overall pick). |
| Drafted SP Tracy Martin in the 2021 first-year player draft (Round 1, Pick 13, 13th overall pick). |
| Drafted 3B Jeff Parker in the 2021 first-year player draft (Round 1, Pick 15, 15th overall pick). |
| Drafted C Terry Faulkner in the 2021 first-year player draft (Round 1, Pick 22, 22nd overall pick). |
| Drafted 2B Domingo Valdés in the 2021 first-year player draft (Round 2, Pick 7, 39th overall pick). |
| Drafted MR Jeremy Roberson in the 2021 first-year player draft (Round 2, Pick 8, 40th overall pick). |
| Drafted 3B Jerry Moore in the 2021 first-year player draft (Round 2, Pick 14, 46th overall pick). |
| Drafted C Franco Guzmán in the 2021 first-year player draft (Round 2, Pick 20, 52nd overall pick). |
| Drafted 2B Jason Dickinson in the 2021 first-year player draft (Round 2, Pick 23, 55th overall pick). |
| Drafted C Alfonso Casas in the 2021 first-year player draft (Round 3, Pick 1, 65th overall pick). |
| Drafted MR Alec Walker in the 2021 first-year player draft (Round 3, Pick 9, 73rd overall pick). |
| Drafted MR Ángel Morales in the 2021 first-year player draft (Round 3, Pick 10, 74th overall pick). |
| Drafted 2B Chris Hennessey in the 2021 first-year player draft (Round 3, Pick 12, 76th overall pick). |
| Drafted CF John Kelley in the 2021 first-year player draft (Round 4, Pick 5, 102nd overall pick). |
| Drafted SP Keith Fraser in the 2021 first-year player draft (Round 4, Pick 8, 105th overall pick). |
| Drafted SP Ken Phillips in the 2021 first-year player draft (Round 4, Pick 23, 120th overall pick). |
| Drafted MR Jon Green in the 2021 first-year player draft (Round 4, Pick 29, 126th overall pick). |
| Drafted 1B Bill Thomas in the 2021 first-year player draft (Round 5, Pick 5, 136th overall pick). |
| Drafted MR Charles Lacy in the 2021 first-year player draft (Round 5, Pick 14, 145th overall pick). |
| Drafted CF Juan McNeill in the 2021 first-year player draft (Round 6, Pick 5, 177th overall pick). |
| Drafted CF Cristián Alea in the 2021 first-year player draft (Round 7, Pick 5, 212nd overall pick). |
| Drafted MR Ted Whitaker in the 2021 first-year player draft (Round 8, Pick 5, 236th overall pick). |
| Drafted 2B Ramón Sánchez in the 2021 first-year player draft (Round 9, Pick 5, 260th overall pick). |
| Drafted SP Dennis Joyce in the 2021 first-year player draft (Round 10, Pick 5, 284th overall pick). |
